Colorectal cancer target referralcancer detection rate and diagnostic Essay

Colorectal cancer target referralcancer detection rate and diagnostic efficacy of the criteria - Essay Example Etiology of colorectal carcinoma is not clear but a few etiological factors have been implicated. These are as under, 1. Geographic variations: The incidence of large bowel carcinoma shows wide variation throughout the world. It is much more common in North America, Northern Europe, then in South America, Africa, and Asia. Colorectal cancer is generally thought to be a disease of affluent societies because its incidence is directly correlated with the socioeconomic status of the countries. 2. Dietary factors: Diet plays a significant part in the causation of colorectal cancer. A low intake of vegetable fiber-diet leading to low stool bulk is associated with higher risk of colorectal carcinoma. Consumption of large amounts of fatty foods by populations results in excessive cholesterol and their metabolites which may be carcinogenic. Excessive consumption of refined carbohydrates that remain in contact with colonic mucosa for prolonged duration changes the bacterial flora of the bowel, thus resulting in production of carcinogenic substances. 3. Adeno-carcinoma sequence: There is strong evidence to suggest that colonic adenoma-carcinoma arises from pre-existing adenomas referred to as adeno-carcinoma sequence. Incidence of adenomas in population is directly proportional to the prevalence of colorectal cancer. 4. ... cular genetics have revealed that there are sequential multi-step mutations in evolution of colorectal cancer from adenomas by mechanisms such as -catenin mechanism and microsatellite instability mechanism. Distribution of the primary colorectal cancer reveals that about 60% of the cases occur in the rectum, followed in descending order, by sigmoid and descending colon (25%), caecum and ileocaecal valve (10%), ascending colon, hepatic and splenic flexures (5%); and quite uncommonly in the tranverse colon. Clinical symptoms in colorectal cancer appear after considerable time. These include occult bleeding, changes in bowel habits, loss of weight ( cachexia), loss of appetitie (anorexia), anemia, weakness, malaise. The most common complications are obstruction and hemorrhage; less often perforation and secondary infection may occur. The prognosis of colorectal cancer depends upon few variables such as extent of bowel movement, presence or absence of metastases, histological grade of tumor and location of the tumor. The most important prognostic factor in CRC is however, the stage of the disease at the time of diagnosis. Three staging systems are in use. They include Duke's ABC staging, Astler - Coller Staging which is a further modification of Duke's Staging and TNM staging described by American Joint Committee (Mohan 601). The methods used in the diagnosis of CRC are as follows: Fecal Occult Blood Testing (FOBT) FOBT is one of the most effective methods for colorectal cancer screening. Reports reveala reduction in colorectal cancer mortality of 12%-33% in a long-term follow up available in four randomized controlled trials and three non-randomized trials of 330,000 and 200,000 individuals respectively. FOBT isvery acceptable as it is non-invasive,programme.

Debate the influence of welfare state regimes on health inequalities Assignment

Debate the influence of welfare state regimes on health inequalities - Assignment Example studies of research reveal that in the South European countries the family oriented welfare systems are found to be not addressing properly ill health concerns of the disadvantaged groups. But in Scandinavian countries there has been a greater distribution of welfare regime helping the disadvantaged but proper educational directives; relative deprivation as well as class patterned health behaviors has widened the health inequalities in these countries (Eikemo et al, 2008, pp.578-579). Thus it can be concluded that the welfare regimes are not appropriate in their services to the population in a fruitful manner and the developed continent like Europe are also entrapped with provision of rampant health inequalities. This calls for a rigid counteractive measure (proper education, awareness, strict policies and so on) and scrutinizing the loopholes as compromising health is compromising national treasure. Eikemo et al, (2008), Health inequalities according to educational level in different welfare regimes: a comparison of 23 European countries, Vol. 30 No. 4, pp. 565–582, Sociology of Health &

Challenges and Contributions of Feminism to Organizational Theories Term Paper

Challenges and Contributions of Feminism to Organizational Theories - Term Paper Example Additionally, feminism must be seen as something that creates a totally different way of looking at the genders in that women are not inferior beings. Consequently, feminism challenges old assumptions about the sexes. Feminism can be treated in a number of ways. In certain circumstances, it may be seen as something that is a union of ideologies. This is because unlike many other beliefs, it can be the incorporation of both intellectual as well as social movements. Many experts have argued that feminism lacks objectivity and as such may not be regarded as a whole genus. However, this is beside the point; many other philosophies grew out of a postulation by a certain individual or expert. However, in the case of feminism, the idea grew out of the experiences and times of women. Consequently, one cannot be called a feminist if they do not demonstrate any sort of commitment to activism. Feminism must be a combination of ideology, philosophy, and activism. In other situations, feminism may be treated as a historical aspect. However, today, feminism in the UK and other western countries may be regarded as the fight against institutionalized prejudices against the genders within organizations. In other words, feminism may have changed substantially over the years but all these historical moments have certain things in common; the commitment to reinforcing equality of the sexes. It should be noted that feminism should not be regarded as an ideology that attempts to eliminate men or women out of positions of power. Consequently, one must be able to recognize the fact that feminism understands the differences between men and women but seeks to look for ways in which these two genders can co-exist in harmony.